Warshadda Insulin: Ma Daaweyneysaa Sonkorowga? Faa'iidooyinka, Qiyaasta & Khataraha

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Warshadda insulin-ta waxaa loo soo bandhigay Hindiya muddooyinkii ugu dambeeyay. Geedka waxaa loo arkaa inuu yahay sixir, daawo dabiici ah oo loogu talagalay cudurka macaanka. In kasta oo geedaha loo adeegsado daaweynta sonkorowga, haddana waxay faa'iido u leedahay daaweynta dhagxaanta kelyaha, dhiig karka ^[1] iyo xanuuno kale oo kala duwan.

Daraasado ayaa shaaca ka qaaday koror ballaaran oo ku saabsan baahsanaanta kiisaska sonkorowga ee Hindiya, shantii sano ee la soo dhaafay. Taas oo kordhinaysa baahida dhirta ee dalka. Waxtarka dhirta ee daaweynta ^[laba] cudurka macaanka waxaa lagu soo ururin karaa oraahda ah, 'caleen dhirta insulin ah maalintii ayaa kaadi macaanka ka celisa'.

Xigasho: Wikipedia

Faa'iidooyinka badan ee ay bixiso geedka, sidaan horay u soo sheegnay kuma koobna shaqsiyaadka la dhibaataysan ^[3] sonkorowga. Faa'iidooyinka ay bixiso geedka ayaa faa'iido u yeelan kara qof kasta oo caafimaadka ka welwelsan. Akhriso si aad waxbadan uga ogaato waxtarka daawada cudurka macaanka ee mucjisada.

Kiimikada jirka kujirta ee kujirta dhirta insulin-ta

Daraasad ay sameeyeen Hegde, Rao iyo Rao oo ku saabsan geedka insulin-ka ayaa shaaca ka qaaday in geedka joogtada ahi uu hodan ku yahay birta, borotiinka, iyo qaybaha antioxidant sida ^[4] α-tocopherol, ascorbic acid, steroids, β-carotene, terpenoids, iyo flavonoids.

Daraasad kale, waxaa lagu ogaadey in ^[5] soosaarida methanolic ee dhirta waxay laheyd boqolkiiba sare ee phytochemicals sida karbohaydraytyada, borotiinada, triterpenoids, alkaloids, saponins, tannins, iyo flavonoids.

Markii la baarayay caleemaha geedka, ayaa la muujiyay ^[6] in ay ka kooban tahay 21.2% fiber, 5.2% soosaara shidaal ether, 1.33% acetone, 1.06% cyclohexane iyo 2.95% ethanol. Qaybaha kale ee la helay waxay ahaayeen terpeenoid compound lupeol iyo stigmasterol istiraatiiji ah oo ku dhex jirta jirida geedka. Rhizome-ka, xeryahooda bioactive sida quercetin iyo diosgenin ayaa laga helay.

Rhizomes-ka iyo caleemaha ayaa ku jira ^[7] xaddiga potassium, kaalshiyam, chromium, manganese, copper iyo zinc.

Faa'iidooyinka Caafimaad ee Warshadda Insulin

Laga soo bilaabo hagaajinta heerarka sonkorta dhiigga ilaa hagaajinta dheef-shiidka, faa'iidooyinka geedaha waa kuwo aan xad lahayn.

1. Wuxuu daaweeyaa cudurka macaanka

Dhirtu waxay ku shaqaysaa waxyaabo yaab leh iyadoo yaraysa heerka sonkorta ee dhiiggaaga ku jirta. Waxyaabaha fructose ee ku jira caleemaha insulinta ayaa nidaamiya heerarka sonkorta, iyagoo ku ilaalinaya gudaha ^[8] heerka loo baahan yahay. Cunitaanka joogtada ah ee caleemaha ayaa kaa caawin kara kahortagga bilawga dhibaatooyinka caafimaad ee daba dheeraaday ee ku soo kordhay sonkorowga. Sida ^[9] socodka nafaqada ee aan la xakamayn karin ee jidhka ku jira iyo waliba xubnaha oo ku fashilma. Diin-jeex laga sameeyay caleemaha ayaa ah daaweynta ugu fiican ^[10] sonkorowga.

2. Waxay hagaajisaa dheefshiidka

Qaybaha kala duwan ee isku dhafan, fiitamiinnada iyo nafaqooyinka ku jira geedaha waxaa lagu caddeeyay inay u shaqeeyaan si la mid ah bakteeriyada E.coli, taas oo hagaajinaysa ^{kow iyo toban} habka dheefshiidka. Adoo matalaya sida pre-biotic dabiici ah, waxay dhaqaajisaa dheefshiidka. Kordhinta bakteeriyada wanaagsan ee nidaamka dheef-shiidka waxay ku caawineysaa nuugista saxda ah ee nafaqooyinka. Sidoo kale, heerka fructose wuxuu gacan ka geysanayaa hagaajinta shaqada xiidanka, fudeynaya geeddi-socodka saxarada.

3. Waxay leedahay astaamaha antioxidant

Daraasado ayaa daaha ka qaaday in dhirta insulin-ta ay leedahay iskudhisyo dabiici ah antioxidative. Hantida antioxidative ee geedaha ayaa baabi'iya ^[12] xagjirnimo bilaash ah, taas oo ilaalinaysa jirkaaga iyo unugyadaada. Waxyaalaha antioxidant ee geedaha waxay ku urursan yihiin soosaarida methanolic ee laga helo rhizomes iyo caleemaha geedka.

4. Waxay maamushaa diuresis

Dhirtu waxay leedahay awooda soodhiyamka iyo haynta biyaha, taas oo ka dhigaysa qayb muhiim ah hagaajinta kaadiheystaada iyo caafimaadka kalyaha. Rhizomes-ka iyo ^[13] caleemaha dhirta waxay leeyihiin hanti lagu durayo oo ay maamusho daawada diuresis.

5. Waxay leedahay astaamo lidka bakteeriyada

Soosaarida methanolic ee geedka waxay ka ilaalisaa jirkaaga noocyada gram-positive sida Bacillus megaterium, Bacillus cerus, Staphylococcus aureus iyo ^[14] noocyo kala duwan oo gram-negative ah sida Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, iyo Salmonella typhimurium. Waxay dishaa dhibaatada keenta bakteeriyada waxayna siisaa gargaar habka soo-bixidda.

6. Wuxuu daaweeyaa dhibaatooyinka beerka

Warshadda insulin waxay ka caawisaa inay jabiso dufanka ku jira iyo sunta aan loo baahnayn ee beerka ku jira. Adoo ka saaraya sunta jirkaaga, geedaha ayaa xaddidaya horumarka ^{[shan iyo toban]} cudurada raaga mustaqbalka. Jebinta astaamaha dufanka waxay gacan ka geysaneysaa hagaajinta shaqada beerka sidoo kale. Cunista joogtada ah ee geedaha waa xal wax ku ool ah oo lagu daaweeyo dhibaatooyinka beerka.

7. Waxay wanaajisaa caafimaadka kaadi haysta

Ahaanshaha dabiici ahaan, dhirta insulin-ta waxay waxtar u leedahay daaweynta dhibaatooyinka la xiriira nidaamka kaadiheysta. Isticmaalka joogtada ah ee geedaha ayaa kaa caawin kara ^[16] kicinta shaqada saxda ah ee kaadiheystaada, iskana ilaaliso halista infekshin kasto.

8. Wuxuu kobciyaa xasanaadka

Waxyaabaha antioxidant-ka ee geedaha ayaa waxtar u leh hagaajinta jirkaaga ^[17] habka difaaca jirka. Warshadda insulin waxay baabi'isaa sunta sida xagjirnimada bilaashka ah waxayna caawisaa horumarinta habka difaaca jirka oo caafimaad qaba. Isticmaalka joogtada ahi wuxuu hagaajin karaa habka difaaca jirka wuxuuna jidhkaaga ka ilaalin karaa cudur kasta.

9. Waxay ka hortagtaa kansarka

Daraasado ayaa shaaca ka qaaday in dhirta insulin-ta ay leedahay waxyaabo antiproliferative iyo anticancer. Iyada oo ay weheliso dabeecaddeeda antioxidant, geedaha ayaa ka caawiya iyada oo laga saarayo xagjirnimada bilaashka ah ee keena kansarka. Waxaa la hubiyey in geedo yaryar ay si gaar ah waxtar ugu leeyihiin daaweynta ^[18] HT 29 iyo unugyada A549. Cunista joogtada ah ee geedaha waxay kaa caawineysaa kahortagga koritaanka unugyada kansarka ee jirkeena.

10. Waxay yareysaa heerarka kalastarolka

Geedaha insulin-ta ayaa hodan ku ah qaybaha biyaha ku milma ee ka caawiya hoos u dhigista nuugista gulukooska ee nidaamka dhiigga [4]. Adoo gaabinaya howsha, waxay nidaamineysaa dhuuqista sonkorta iyo soosaarka insulin ee jirka. Nuugista tartiib-tartiibku waxay keentaa nuugista saxda ah ee ka kooban dufanka sidaas awgeed, taasoo keentay hoos u dhaca heerarka kolestaroolka dhiigga. Markaa, geedo yaryar ayaa ka caawiya jirkaaga inuu u dhaco halista wadno-qabadka, istaroogga, ama kansarka.

11. Wuxuu daweeyaa cuna xanuun

Mid ka mid ah astaamaha kale ee geedaha mucjisada ahi waa astaamaha ka hortagga bararka. Cunitaanka geedaha ayaa kaa caawin kara daaweynta cune xanuun iyo astaamaha boronkiitada maadaama ay u soo baxday sababo la xiriira [19] caabuq ku dhaca marin-haweedkaaga. Warshadda insulin-ta waxay yareyn doontaa caabuqa waxayna daaweyn doontaa xaaladda.

12. Waxay yareysaa dhiig karka

Geedaha insulinta ayaa lagu yaqaan inay hoos udhacaan ^[labaatan] dhiig-kar. Cunitaanka joogtada ah ee geedaha ayaa kaa caawin doona yareynta heerarka sare ee dhiig karka iyo dejinta wadnaha.

13. Wuxuu daaweeyaa cudurka neefta

Sidaan horeyba u soo sheegnay, warshadu waxay leedahay astaamo anti-bararka oo ka caawiya nadiifinta wixii caabuq ah ee ku dhaca hawo mareenka. Waxay ka caawisaa daaweynta ^[19] neefta adoo dejinaya muruqyada sambabaha ee adkeeya bilowga cudurka neefta.

Qiyaasta dhirta Insulin-ta

Kali ahaan waxay kuxirantahay xaalada jireed ee qofka, qiyaasta si sax ah looma cayimin. Si kastaba ha noqotee, si loo helo faa'iidooyinka caafimaad ee ay bixiso geedo yaryar, waxaa lagu talinayaa in la cuno ugu yaraan laba jeer maalintii. Isticmaalkeeda in ka badan laba jeer ayaa leh ^{[kow iyo labaatan]} aysan keenin wax saameyn ah, laakiin la tasho dhakhtar haddii aad rabto inaad kordhiso qiyaastaada.

Waad cuni kartaa subaxa hore iyo hal jeer intaadan seexan habeenkii. Geedka insulin-ta waxaa loo isticmaali karaa inuu yahay qashin (caleemaha laga soo saaro), ama insulinta caleenta shaaha ayaa laga dhigi karaa inay ku raaxeysato waxtarkeeda caafimaad.

Sida Loo Sameeyo Caleenta Caleenta Insulin

• Xullo farabadan insulin caleenta (10-15) kuna maydh biyo socda ^[22] .
• Caleemaha u jarjar qaybo yaryar oo ku qallaji qorraxda hoosteeda.
• Waxaad ku hubin kartaa qalajinta caleemaha adoo tuujinaya.
• Marka caleemaha la qalajiyo, ku kaydso weel hawo-mareenka ah.
• Koob biyo ah qaado oo karkari.
• Marka la karkariyo, ku shub biyaha galaas ay ku jiraan caleemaha dhirta insulin-ta la qalajiyey.
• Sug ilaa ay biyuhu ka noqdaan bunni.
• Cab cabitaanka si joogto ah natiijooyinka togan.

Cunto caafimaad

1. Insuliintu waxay ka tagtaa shaaha

Waxyaabaha ay ka kooban tahay ^[22]

• 5-7 caleemo insulin ah
• 4 koob oo biyo ah
• Malabka dhadhanka

Tilmaamaha

• Maydh caleemaha oo ha u qalasho.
• Ku kari biyaha dheriga dhexdiisa.
• Markay biyuhu bilaabaan inay karkaraan, ku dar caleemaha.
• U oggolow inuu karkariyo, illaa ay biyuhu ka yareeyaan hal koob.
• Shaaha shaandhee shaaha ku shub koob.
• Ku dar malab dhadhanka.

Saameynada Ay Leedahay Geedka Insulin

Sidii caadada u ahayd, geedo kasta oo heysta waxtar badan waxay ku xirnaan doonaan inay ku soo biiraan halista qaar. Marka laga hadlayo dhirta insulin-ta, kama duwana.

• Haweenka uurka leh iyo kuwa nuujinaya waa inay ka fogaadaan, maxaa yeelay geedo yaryar ayaa saameyn ku yeelan kara dheelitirka hoormoonka.
• Iska ilaali inaad si toos ah u cuntid caleemaha dhadhanka iyo saamaynta adag awgeed waxay sababi karaan dareen gubasho.

1. [1]Benny, M. (2004). Geedka insulinta ee jardiinooyinka.
2. [laba]Bhat, V., Asuti, N., Kamat, A., Sikarwar, M. S., & Patil, M. B. (2010). Waxqabadka Antidiabetic ee dhirta insulin (Costus igneus) laga soosaaray caleemaha jiirka sonkorowga. Joornaalka Cilmi-baarista Farmashiyaha, 3 (3), 608-611.
3. [3]Shetty, A. J., Choudhury, D., Rejeesh, V. N., Kuruvilla, M., & Kotian, S. (2010). Saameynta dhirta insulin-ta (Costus igneus) waxay ku baxdaa 'hyperglycemia' oo loo yaqaan 'dexamethasone-induced hyperglycemia.'
4. [4]Hegde, P. K., Rao, H. A., & Rao, P. N. (2014). Dib-u-eegis ku saabsan dhirta 'Insulin' (Costus igneus Nak). Dib u eegista Pharmacognosy, 8 (15), 67.
5. [5]Jothivel, N., Ponnusamy, S. P., Appachi, M., Singaravel, S., Rasilingam, D., Deivasigamani, K., & Thangavel, S. (2007). Waxqabadka anti-sonkorowga ee laga soosaaray caleenta methanol ee Costus pictureus D. Don ee jiirka sonkorowga ee alloxan. Joornaalka Sayniska Caafimaadka, 53 (6), 655-663.
6. [6]George, A., Thankamma, A., Devi, V., & Fernandez, A. (2007). Baadhitaanka phytochemical ee warshadda insulin (Costus pictus) .Asia Journal of Chemistry, 19 (5), 3427.
7. [7]Jayasri, M. A., Gunasekaran, S., Radha, A., & Mathew, T. L. (2008). Saameynta ladagaalanka sokorowga ee 'Costus pictus leaves' wuxuu ku baxayaa jiirka sonkorowga ee caadiga ah iyo kuwa loo yaqaan 'streptozotocin-induced sonkorta' .I J J Sonkorowga Metab, 16, 117-22.
8. [8]Urooj, A. (2008). Awoodda Hypoglycemic ee Morus indica. L iyo Costus igneus. Nak. — Daraasad hordhac ah.
9. [9]Bhat, V., Asuti, N., Kamat, A., Sikarwar, M. S., & Patil, M. B. (2010). Waxqabadka Antidiabetic ee dhirta insulin (Costus igneus) laga soosaaray caleemaha jiirka sonkorowga. Joornaalka Cilmi-baarista Farmashiyaha, 3 (3), 608-611.
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11. kow iyo tobanSulakshana, G., & Rani, A. S. (2014). Falanqaynta HPLC ee diosgenin ee saddexda nooc ee Costus. Isnt J Pharm Sci Res, 5 (11), 747-749.
12. [12]Devi, D. V., & Asna, U. (2010). Nooca nafaqada iyo qaybaha ka hortagga jirka ee 'Costus speciosus Sm'. iyo Costus igneus Nak Indian Journal of Natural Products and Resources, 1 (1), 116-118.
13. [13]Sulakshana, G., Rani, A. S., & Saidulu, B. (2013). Qiimeynta waxqabadka bakteeriyada ee saddexda nooc ee Costus. Joornaalka Caalamiga ah ee Microbiology ee hadda jira iyo Sayniska la adeegsado, 2 (10), 26-30.
14. [14]Nagarajan, A., Arivalagan, U., & Rajaguru, P. (2017). Soosaarida xididdada 'vitro' iyo daraasadaha ku saabsan waxqabadka bakteeriyada ee ka soo saarista xididka 'Costus igneus' ee ku saabsan cudur-sidaha jirka ee aadamaha muhiim u ah. Joornaalka Microbiology iyo Cilmi-baarista Biotechnology, 1 (4), 67-76.
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